I'm not entirely sure if Flight 7500 is based on a true story, but it does seem to be inspired by real life events. The plot of the film revolves around a group of passengers who experience some weird and unexplainable occurrences during a flight from Los Angeles to Tokyo. There have been a few reports of similar strange occurrences on flights, but nothing has been proven. Personally, I think the film is more about exploring the human psyche and how people react to the unexpected and unexplainable.