There is no one definitive answer to this question, as it can depend on a number of factors. However, it is generally difficult for self-published authors to get their books picked up by traditional publishers. This is because self-published books are often not of the same quality as books that have gone through the traditional publishing process, and because they do not have the same built-in marketing and distribution channels.
That being said, there are self-published authors who have been able to successfully get their books picked up by traditional publishers. This usually happens when the author has already built up a significant following for their work, and when the book is particularly well-written and well-crafted. In these cases, the traditional publisher can see the potential for the book to be successful, and they are willing to take on the risk of publishing it.
If you are a self-published author interested in getting your book picked up by a traditional publisher, your best bet is to focus on building up a passionate and engaged fan base for your work. Once you have a large enough following, you can approach publishers with your book and try to negotiate a deal.