This is a tough question because there are so many great thrillers out there. However, if we narrow it down to the bestseller list, then the clear winner is Gone Girl by Gillian Flynn.
Gone Girl is a psychological thriller that tells the story of a married couple, Nick and Amy Dunne, who have hit a rough patch in their relationship. When Amy suddenly goes missing on their fifth anniversary, Nick becomes the prime suspect in her disappearance.
The novel is told from alternating points of view, which keeps readers guessing about what really happened to Amy. Gone Girl is a page-turner that will keep you on the edge of your seat until the very end.