The placement of an image on a shirt depends on the desired effect. For example, if you want the image to be the center of attention, you would place it in the middle of the shirt. However, if you want the image to be more subtle, you might place it on the left or right side of the shirt. Additionally, the size of the image also affects its placement. For example, a large image would look best in the center of the shirt, while a smaller image could be placed on the left or right side.