It depends on the context. If you’re talking about creation, then it would be “creation” without the “s”. Creation refers to the act of bringing something into existence, or the product of that act. For example, “the creation of a new species” or “the creation of a beautiful painting”.
If you’re talking about “creations”, then you’re referring to something that has already been created. This could include works of art, literature, music, scientific discoveries, or any other products of the creative process. For example, “the artist’s creations” or “the scientist’s creations”.
So, the answer to your question depends on the context and what you’re referring to. If you’re talking about the creative process, then use “creation”. If you’re talking about the products of the creative process, then use “creations”.