The answer to this question is subjective since one person’s favorite painting may not be another’s. However, there is an agreement among art historians, collectors and art lovers that the most famous painting in the world is Leonardo da Vinci’s Mona Lisa. This iconic painting has been the subject of books, movies, songs, and stolen pieces of art all over the world. It is also the most expensive painting ever sold, having been auctioned in November 2017 for $450 million. This makes the Mona Lisa one of the most recognizable and treasured works of art in the world.