Yes, book titles are usually italicized in Chicago style. This is generally true for titles of any long work, including books, journals, newspapers, and magazines. There are some exceptions, however. For instance, if a book is part of a series, the title of the series might be italicized while the title of the book is in quotation marks. Alternatively, some publishers or style guides may choose to use sentence case for titles, which would mean that only the first word and proper nouns would be capitalized. You should always check with your instructor or editor to see what style they prefer.
